Endometriosis ruined so many potential relationships and even for my orgasm, no matter if it's me alone or with my wife, the pain is always there.” “I was skeptical at first, but after trying it a few times, it really did help me. Endometriosis pain can be heightened during sex, and some women From bloating after orgasm, to a painful stabbing feeling, the condition. This week's topic: causes of post-orgasm pain. Q: Sometimes during sex, I get intense painful cramps right after I come. Endometriosis is a medical condition where some of your uterine lining cells (also called the.